The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis.

doi:10.1002/ajmg.b.32907

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2022

Hindley Guy, O'Connell Kevin S, Rahman Zillur, Frei Oleksandr, Bahrami Shahram, Shadrin Alexey, Høegh Margrethe C, Cheng Weiqiu, Karadag Naz, Lin Aihua, Rødevand Linn, Fan Chun C, Djurovic Srdjan, Lagerberg Trine V, Dale Anders M, Smeland Olav B, Andreassen Ole A

Abstract excerpt

Recent genome-wide association studies of mood instability (MOOD) have found significant positive genetic correlation with major depression (DEP) and weak correlations with other psychiatric disorders. We investigated the polygenic overlap between MOOD and psychiatric disorders beyond genetic correlation to better characterize putative shared genetic determinants. GWAS summary statistics for schizophrenia (SCZ,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Associations and Epidemiology

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Major Depressive Disorder

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 35841185
DOI: 10.1002/ajmg.b.32907
PMCID: PMC9541703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis.PMID 35841185Read ↗

Genome-wide association analysis reveals extensive genetic overlap between mood instability and psychiatric disorders but divergent patterns of genetic effectsSemantic proximity Read ↗

Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia.Semantic proximity Read ↗

The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and functionSemantic proximity Read ↗

The genetics of the mood disorder spectrum: genome-wide association analyses of over 185,000 cases and 439,000 controlsSemantic proximity Read ↗

The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 ControlsSemantic proximity Read ↗

Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings.Semantic proximity Read ↗

Novel loci and potential mechanisms of major depressive disorder, bipolar disorder, and schizophrenia.Semantic proximity Read ↗

Overlapping common genetic architecture between major depressive disorders and anxiety and stress-related disorders.Semantic proximity Read ↗

Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbiditiesSemantic proximity Read ↗

Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilitiesSemantic proximity Read ↗

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.