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Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses

25 Apr 2024

Abstract excerpt

Broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin (HA) stem of influenza A viruses (IAVs) tend to be effective against either group 1 or group 2 viral diversity. In rarer cases, intergroup protective bnAbs can be generated by human antibody paratopes that accommodate the conserved glycan differences between the group 1 and group 2 stems. We applied germline-engaging nanoparticle immunogens to...

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PMID: 38670113
DOI: 10.1016/j.immuni.2024.03.022

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