Article
Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design.
Clinical epigenetics - 10 Aug 2022
Hillary Robert F, McCartney Daniel L, McRae Allan F, Campbell Archie, Walker Rosie M, Hayward Caroline, Horvath Steve, Porteous David J, Evans Kathryn L, Marioni Riccardo E
Abstract excerpt
BACKGROUND: CpG methylation levels can help to explain inter-individual differences in phenotypic traits. Few studies have explored whether identifying probe subsets based on their biological and statistical properties can maximise predictions whilst minimising array content. Variance component analyses and penalised regression (epigenetic predictors) were used to test the influence of (i) the number of probes...
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