Article
RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood.
Genome biology - 10 Dec 2025
Navarro-Delgado Erick I, Czamara Darina, Edwards Karlie, Fu Maggie P, Merrill Sarah M, Konwar Chaini, MacIsaac Julie L, Lin David T S, Mandhane Piush, Simons Elinor, Subbarao Padmaja, Moraes Theo J, Lahti Jari, Miller Gregory E, Binder Elisabeth B, Räikkönen Katri, Turvey Stuart E, Korthauer Keegan, Kobor Michael S
Abstract excerpt
Genetic variation and environmental exposures are amongst the main factors associated with inter-individual DNA methylation variability. However, the prevalence and genomic context of individual, additive, and interactive gene-environment effects remains unclear. We present RAMEN, an R package that dissects genome-exposome contributions to microarray Variably Methylated Loci using machine learning and statistical...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.