Genetically Predicted Levels of DNA Methylation Biomarkers and Breast Cancer Risk: Data From 228 951 Women of European Descent.

doi:10.1093/jnci/djz109

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Article

Genetically Predicted Levels of DNA Methylation Biomarkers and Breast Cancer Risk: Data From 228 951 Women of European Descent.

Journal of the National Cancer Institute - 1 Mar 2020

Yang Yaohua, Wu Lang, Shu Xiao-Ou, Cai Qiuyin, Shu Xiang, Li Bingshan, Guo Xingyi, Ye Fei, Michailidou Kyriaki, Bolla Manjeet K, Wang Qin, Dennis Joe, Andrulis Irene L, Brenner Hermann, Chenevix-Trench Georgia, Campa Daniele, Castelao Jose E, Gago-Dominguez Manuela, Dörk Thilo, Hollestelle Antoinette, Lophatananon Artitaya, Muir Kenneth, Neuhausen Susan L, Olsson Håkan, Sandler Dale P, Simard Jacques, Kraft Peter, Pharoah Paul D P, Easton Douglas F, Zheng Wei, Long Jirong

Abstract excerpt

BACKGROUND: DNA methylation plays a critical role in breast cancer development. Previous studies have identified DNA methylation marks in white blood cells as promising biomarkers for breast cancer. However, these studies were limited by low statistical power and potential biases. Using a new methodology, we investigated DNA methylation marks for their associations with breast cancer risk. METHODS: Statistical...

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Identifiers

PMID: 31143935
DOI: 10.1093/jnci/djz109
PMCID: PMC7073907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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