Article
Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects.
BMC genomics - 17 Nov 2012
van Eijk Kristel R, de Jong Simone, Boks Marco P M, Langeveld Terry, Colas Fabrice, Veldink Jan H, de Kovel Carolien G F, Janson Esther, Strengman Eric, Langfelder Peter, Kahn René S, van den Berg Leonard H, Horvath Steve, Ophoff Roel A
Abstract excerpt
BACKGROUND: The predominant model for regulation of gene expression through DNA methylation is an inverse association in which increased methylation results in decreased gene expression levels. However, recent studies suggest that the relationship between genetic variation, DNA methylation and expression is more complex. RESULTS: Systems genetic approaches for examining relationships between gene expression and...
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