Article

Feature pre-selection for the development of epigenetic biomarkers

2024-02-15

Abstract excerpt

Over the last decade, a plethora of blood-based DNA methylation biomarkers have been developed to track differences in ageing, lifestyle, health, and biological outcomes. Typically, penalised regression models are used to generate these predictors, with hundreds or thousands of CpGs included as potential features. However, in such ultra high-dimensional settings, the effectiveness of these methods may be reduced....

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Literature Corpus work: df7d2747-ee8f-5a43-96ce-1a504b4177f0
DOI: 10.1101/2024.02.14.24302694

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