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Article

Blood-based DNA methylation captures variance in adult height.

Genome biology - 20 Jan 2026

Hatton Alesha A, Hillary Robert F, McCartney Daniel L, Harris Sarah E, Cox Simon R, Evans Kathryn L, Walker Rosie M, Suderman Matthew, Yousefi Paul, McRae Allan F, Marioni Riccardo E

Abstract excerpt

BACKGROUND: While height is a highly heritable trait with strong polygenic prediction, previous studies have postulated that minimal variation of its individual differences can be captured by DNA methylation (DNAm). We investigated the role of blood-based genome-wide DNAm in capturing the variance in adult height in a large population-based cohort of 7,654 unrelated individuals from Generation Scotland using DNAm...

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Identifiers

PMID: 41559797
DOI: 10.1186/s13059-025-03918-7
PMCID: PMC12905977

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