Article
Somatic mutations associate with clonal expansion of CD8+ T cells.
Science advances - 7 Jun 2024
Lundgren Sofie, Myllymäki Mikko, Järvinen Timo, Keränen Mikko A I, Theodoropoulos Jason, Smolander Johannes, Kim Daehong, Salmenniemi Urpu, Walldin Gunilla, Savola Paula, Kelkka Tiina, Rajala Hanna, Hellström-Lindberg Eva, Itälä-Remes Maija, Kankainen Matti, Mustjoki Satu
Abstract excerpt
Somatic mutations in T cells can cause cancer but also have implications for immunological diseases and cell therapies. The mutation spectrum in nonmalignant T cells is unclear. Here, we examined somatic mutations in CD4+ and CD8+ T cells from 90 patients with hematological and immunological disorders and used T cell receptor (TCR) and single-cell sequencing to link mutations with T cell expansions and...
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