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The developmental origins of the mammalian ovarian reserve

1 Aug 2015

Abstract excerpt

The adult mammalian ovary is devoid of definitive germline stem cells. As such, female reproductive senescence largely results from the depletion of a finite ovarian follicle pool that is produced during embryonic development. Remarkably, the crucial nature and regulation of follicle assembly and survival during embryogenesis is just coming into focus. This developmental pathway involves the coordination of...

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PMID: 26243868
DOI: 10.1242/dev.125211

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