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Chromatin remodeler CHD4 establishes chromatin states required for ovarian reserve formation, maintenance and male germ cell survival

6 Jan 2025

Abstract excerpt

The ovarian reserve defines female reproductive lifespan, which in humans spans decades due to the maintenance of meiotic arrest in non-growing oocytes (NGOs) residing in primordial follicles. Unknown is how the chromatin state of NGOs is established to enable long-term maintenance of the ovarian reserve. Here, we show that a chromatin remodeler, CHD4, a member of the Nucleosome Remodeling and Deacetylase (NuRD)...

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PMID: 39907108
DOI: 10.1093/nar/gkaf008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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