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DNA methylation mechanisms in the maturing and ageing oocyte

10 Jun 2025

Abstract excerpt

Oocyte maturation involves both nuclear and cytoplasmic processes that are critical for the acquisition of oocyte competence. Granulosa cells, surrounding the oocyte, play a pivotal role in the maturation process, with mechanisms such as cAMP signaling significantly influencing oocyte development. Epigenetic mechanisms - including DNA methylation and its oxidative derivatives, histone post-translational...

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PMID: 40495235
DOI: 10.1186/s13072-025-00600-x

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