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Article

The Drosophila homologue of MEGF8 is essential for early development.

Scientific reports - 8 Jun 2018

Lloyd Deborah L, Toegel Markus, Fulga Tudor A, Wilkie Andrew O M

Abstract excerpt

Mutations of the gene MEGF8 cause Carpenter syndrome in humans, and the mouse orthologue has been functionally associated with Nodal and Bmp4 signalling. Here, we have investigated the phenotype associated with loss-of-function of CG7466, a gene that encodes the Drosophila homologue of MEGF8. We generated three different frame-shift null mutations in CG7466 using CRISPR/Cas9 gene editing. Heterozygous flies...

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Identifiers

PMID: 29884872
DOI: 10.1038/s41598-018-27076-y
PMCID: PMC5993795

Genes

MEGF8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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