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Article

An LRRTM4-HSPG complex mediates excitatory synapse development on dentate gyrus granule cells.

Neuron - 21 Aug 2013

Siddiqui Tabrez J, Tari Parisa Karimi, Connor Steven A, Zhang Peng, Dobie Frederick A, She Kevin, Kawabe Hiroshi, Wang Yu Tian, Brose Nils, Craig Ann Marie

Abstract excerpt

Selective synapse development determines how complex neuronal networks in the brain are formed. Complexes of postsynaptic neuroligins and LRRTMs with presynaptic neurexins contribute widely to excitatory synapse development, and mutations in these gene families increase the risk of developing psychiatric disorders. We find that LRRTM4 has distinct presynaptic binding partners, heparan sulfate proteoglycans...

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Share to Dentate Gyrus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23911104
DOI: 10.1016/j.neuron.2013.06.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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