Article

Human-specific multicopy gene FRMPD2 promotes synapse formation via recruitment of neuroligin 1

2026-04-08

Abstract excerpt

<h4>ABSTRACT</h4> FRMPD2 is a human-specific multi-copy gene with higher mRNA expression in brain tissue, but its role in synapse formation and neurodevelopment remains unknown. We find that FRMPD2 is a neuron-specific protein with a high expression level in human brains compared to rodent brains. FRMPD2 overexpression in rat neurons stimulates synaptogenesis, leading to increased synaptic activities. Importantly...

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Literature Corpus work: 2477430f-7e8d-594c-9ed7-0873c4090af0
DOI: 10.64898/2026.04.07.716942

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