Article
wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila.
Neuron - 14 Feb 2002
Aberle Hermann, Haghighi A Pejmun, Fetter Richard D, McCabe Brian D, Magalhães Tiago R, Goodman Corey S
Abstract excerpt
We conducted a large-scale screen for Drosophila mutants that have structural abnormalities of the larval neuromuscular junction (NMJ). We recovered mutations in wishful thinking (wit), a gene that positively regulates synaptic growth. wit encodes a BMP type II receptor. In wit mutant larvae, the size of the NMJs is greatly reduced relative to the size of the muscles. wit NMJs have reduced evoked excitatory...
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