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Article

Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk.

Arthritis research & therapy - 8 Aug 2022

Brumwell Abby, Aubourg Guillaume, Hussain Juhel, Parker Eleanor, Deehan David J, Rice Sarah J, Loughlin John

Abstract excerpt

BACKGROUND: Osteoarthritis is highly heritable and genome-wide studies have identified single nucleotide polymorphisms (SNPs) associated with the disease. One such locus is marked by SNP rs11732213 (T > C). Genotype at rs11732213 correlates with the methylation levels of nearby CpG dinucleotides (CpGs), forming a methylation quantitative trait locus (mQTL). This study investigated the regulatory activity of the...

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Source

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Identifiers

PMID: 35941660
DOI: 10.1186/s13075-022-02882-y
PMCID: PMC9358880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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