The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis.

doi:10.1038/gene.2011.23

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Article

The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis.

Genes and immunity - 1 Jul 2011

Pointon J J, Harvey D, Karaderi T, Appleton L H, Farrar C, Wordsworth B P

Abstract excerpt

Associations with disease identified by genome-wide association studies (GWAS) must be replicated and refined to validate causative variants. In the Wellcome Trust Case Control Consortium (WTCCC) GWAS using 14 500 non-synonymous single nucleotide polymorphisms (nsSNP), rs11062385 (a nsSNP in JARID1A) showed nominal association with ankylosing spondylitis (AS) (P=0.0006, odds ratio (OR)=1.26, 95% confidence...

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PMID: 21562575
DOI: 10.1038/gene.2011.23

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