Article
Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage.
Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2015
den Hollander Wouter, Ramos Yolande F M, Bomer Nils, Elzinga Stefan, van der Breggen Ruud, Lakenberg Nico, de Dijcker Wesley J, Suchiman H Eka D, Duijnisveld Bouke J, Houwing-Duistermaat Jeanine J, Slagboom P Eline, Bos Steffan D, Nelissen Rob G H H, Meulenbelt Ingrid
Abstract excerpt
OBJECTIVE: To identify osteoarthritis (OA) progression-modulating pathways in articular cartilage and their respective regulatory epigenetic and genetic determinants in end-stage disease. METHODS: Transcriptional activity of CpG was assessed using gene expression data and DNA methylation data for preserved and lesional articular cartilage samples. Disease-responsive transcriptionally active CpG were identified by...
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