Article

IL-27 neutralization enhances macrophage polarization and improves immune checkpoint efficacy

2024-09-18

Abstract excerpt

Tumor-associated macrophages (TAMs) accumulate in most solid tumors, where they secrete inflammatory cytokines and growth factors that promote tumor progression, immune evasion, and angiogenesis. TAMs have recently emerged as therapeutic targets for reactivating antitumor immunity and restraining tumor progression. In this study, we investigated whether IL-27 neutralization could modulate macrophage polarization a...

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Literature Corpus work: 32e49701-1e51-526f-ac6c-184c8caee3ed
DOI: 10.1101/2024.09.13.612803

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