Article
Cohesin ATPase activities regulate DNA binding and coiled-coil configuration.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2022
Xu Xingya, Kanai Ryuta, Wang Li, Yanagida Mitsuhiro
Abstract excerpt
The cohesin complex is required for sister chromatid cohesion and genome compaction. Cohesin coiled coils (CCs) can fold at break sites near midpoints to bring head and hinge domains, located at opposite ends of coiled coils, into proximity. Whether ATPase activities in the head play a role in this conformational change is yet to be known. Here, we dissected functions of cohesin ATPase activities in cohesin...
Topics
- Adenosine Triphosphatases
- Amino Acid Substitution
- Cell Cycle Proteins
- Chromosomal Proteins, Non-Histone
- Chromosome Segregation
- DNA
- Mutation
- Protein Domains
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins