Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cohesin ATPase activities regulate DNA binding and coiled-coil configuration.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2022

Xu Xingya, Kanai Ryuta, Wang Li, Yanagida Mitsuhiro

Abstract excerpt

The cohesin complex is required for sister chromatid cohesion and genome compaction. Cohesin coiled coils (CCs) can fold at break sites near midpoints to bring head and hinge domains, located at opposite ends of coiled coils, into proximity. Whether ATPase activities in the head play a role in this conformational change is yet to be known. Here, we dissected functions of cohesin ATPase activities in cohesin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Chromosome Segregation

Share to Cohesins

Share to Protein Domains

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 35939705
DOI: 10.1073/pnas.2208004119
PMCID: PMC9388089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cohesin ATPase activities regulate DNA binding and coiled-coil configuration.PMID 35939705Read ↗

Site-to-site mutational dissection of fission yeast cohesin reveals its dynamics.Semantic proximity Read ↗

Cohesin organization, dynamics, and subdomain functions revealed by genetic suppressor screening.Semantic proximity Read ↗

Pds5 regulates sister chromatid cohesion by controlling cohesin ATPase activity through the Eco1-Smc3 acetylation pathway.Semantic proximity Read ↗

Cohesin acetylation and ATPase activity control cohesion and loop architecture through distinct mechanisms.Semantic proximity Read ↗

Identification of a region in the coiled-coil domain of Smc3 that is essential for cohesin activity.Semantic proximity Read ↗

Conserved disruptions in the predicted coiled-coil domains of eukaryotic SMC complexes: implications for structure and function.Semantic proximity Read ↗

CTCF/cohesin-binding sites are frequently mutated in cancer.Semantic proximity Read ↗

Structure of the human cohesin inhibitor Wapl.Semantic proximity Read ↗

A new twist in the coil: functions of the coiled-coil domain of structural maintenance of chromosome (SMC) proteins.Semantic proximity Read ↗

ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding.Semantic proximity Read ↗

Suppressor mutation analysis combined with 3D modeling explains cohesin's capacity to hold and release DNA.Semantic proximity Read ↗

Genetic evidence that the acetylation of the Smc3p subunit of cohesin modulates its ATP-bound state to promote cohesion establishment in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.