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Article

Suppressor mutation analysis combined with 3D modeling explains cohesin's capacity to hold and release DNA.

Proceedings of the National Academy of Sciences of the United States of America - 22 May 2018

Xu Xingya, Kanai Ryuta, Nakazawa Norihiko, Wang Li, Toyoshima Chikashi, Yanagida Mitsuhiro

Abstract excerpt

Cohesin is a fundamental protein complex that holds sister chromatids together. Separase protease cleaves a cohesin subunit Rad21/SCC1, causing the release of cohesin from DNA to allow chromosome segregation. To understand the functional organization of cohesin, we employed next-generation whole-genome sequencing and identified numerous extragenic suppressors that overcome either inactive separase/Cut1 or...

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Share to Chromatids
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29735656
DOI: 10.1073/pnas.1803564115
PMCID: PMC6003501

Genes

SMC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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