Helminth-induced reprogramming of the stem cell compartment inhibits type 2 immunity

Abstract excerpt

Enteric helminths form intimate physical connections with the intestinal epithelium, yet their ability to directly alter epithelial stem cell fate has not been resolved. Here we demonstrate that infection of mice with the parasite Heligmosomoides polygyrus bakeri (Hpb) reprograms the intestinal epithelium into a fetal-like state marked by the emergence of Clusterin-expressing revival stem cells (revSCs)....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Clusterin in disease pathology
• Share to FOXO transcription factor regulation
• Share to Immune responses and vaccinations