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Article

Emc3 maintains intestinal homeostasis by preserving secretory lineages

30 Mar 2021

Abstract excerpt

Intestinal exocrine secretory lineages, including goblet cells and Paneth cells, provide vital innate host defense to pathogens. However, how these cells are specified and maintained to ensure intestinal barrier function remains poorly defined. Here we show that endoplasmic reticulum membrane protein complex subunit 3 (Emc3) is essential for differentiation and function of exocrine secretory lineages. Deletion of...

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PMID: 33785873
DOI: 10.1038/s41385-021-00399-2

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