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Coevolutionary interplay: Helminths-trained immunity and its impact on the rise of inflammatory diseases

3 Apr 2025

Abstract excerpt

The gut biome, a complex ecosystem of micro- and macro-organisms, plays a crucial role in human health. A disruption in this evolutive balance, particularly during early life, can lead to immune dysregulation and inflammatory disorders. 'Biome repletion' has emerged as a potential therapeutic approach, introducing live microbes or helminth-derived products to restore immune balance. While helminth therapy has...

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PMID: 40231720
DOI: 10.7554/elife.105393

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