Article

Postnatal Reprogramming Shapes Human Intestinal Epithelial Immune Competency

2026-05-08

Abstract excerpt

At birth, the intestine must rapidly adapt to enable nutritional function and immune microbial tolerance. Here, integrating single-cell multi-omics and spatial transcriptomics we define the circuits underpinning this process. We identify asynchronous developmental trajectories with postnatal epithelial reprogramming characterised by coordinated changes in metabolism, junctional structure and innate defence. At bir...

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Literature Corpus work: 6fd21ddd-1f5d-5b49-843d-729cbb4089b5
DOI: 10.64898/2026.05.05.722861

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