Article

TLR2-mediated microbial sensing by intestinal stem cells coordinates epithelial antimicrobial defense

2026-05-07

Abstract excerpt

Intestinal regeneration and host defense require adaptation to environmental cues, but the mechanisms underlying this coordination remain unclear. We show that intestinal Lgr5⁺ stem cells act as luminal sensors via apically localized Toll-like receptor 2 (TLR2), enabling direct detection of microbiota-derived signals. We identify apical TLR2 activation as a mechanism of luminal sensing in adult stem cells and show...

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Literature Corpus work: bafa525b-af08-5bb4-896f-747bb3fa5ce2
DOI: 10.64898/2026.05.04.722581

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