Article
Liver iron levels are associated with HFE-hemochromatosis genotype, diet, adiposity, and disease in the UK Biobank.
Hepatology communications - 1 Feb 2026
Lucas Mitchell R, Pilling Luke C, Delgado João, Williamson Daniel S, Shearman Jeremy D, Hutchison Katharine, Atkins Janice L
Abstract excerpt
INTRODUCTION: HFE genetic variants, especially C282Y homozygosity (C282Y+/+), can increase systemic iron and cause hemochromatosis, though expression varies. Excess iron can lead to liver disease and liver cancer, yet factors influencing liver iron beyond HFE genotype remain unclear. We investigated genetic/environmental factors influencing liver iron, including HFE genotype and hemochromatosis diagnosis....
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