Article

Liver iron levels are associated with<i>HFE</i>-hemochromatosis genotype, diet, adiposity, and disease in the UK Biobank

2025-04-30

Abstract excerpt

<h4>Introduction</h4> HFE genetic variants, especially C282Y homozygosity (C282Y+/+), can increase systemic iron and cause hemochromatosis, though expression varies. Excess iron can lead to liver disease/cancer, yet factors influencing liver iron beyond HFE genotype remain unclear. We investigated genetic/environmental factors influencing liver iron, including HFE genotype and hemochromatosis diagnosis. <h4>Method...

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Literature Corpus work: 9f8d517c-2fb3-53f0-a3b9-27b0c98574a2
DOI: 10.1101/2025.04.29.25322001

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