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Article

XX sex chromosome complement promotes atherosclerosis in mice

14 Jun 2019

Abstract excerpt

Men and women differ in circulating lipids and coronary artery disease (CAD). While sex hormones such as estrogens decrease CAD risk, hormone replacement therapy increases risk. Biological sex is determined by sex hormones and chromosomes, but effects of sex chromosomes on circulating lipids and atherosclerosis are unknown. Here, we use mouse models to separate effects of sex chromosomes and hormones on...

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Share to Cardiovascular, Neuropeptides, and Oxidative Stress Research
Share to Estrogen and related hormone effects
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

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PMID: 31201301
DOI: 10.1038/s41467-019-10462-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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