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Article

Driver mutations of intrahepatic cholangiocarcinoma shape clinically relevant genomic clusters with distinct molecular features and therapeutic vulnerabilities.

Theranostics - 1 Jan 2022

Wang Xiang-Yu, Zhu Wen-Wei, Wang Zheng, Huang Jian-Bo, Wang Sheng-Hao, Bai Fu-Mao, Li Tian-En, Zhu Ying, Zhao Jing, Yang Xin, Lu Lu, Zhang Ju-Bo, Jia Hu-Liang, Dong Qiong-Zhu, Chen Jin-Hong, Andersen Jesper B, Ye Dan, Qin Lun-Xiu

Abstract excerpt

Purpose: To establish a clinically applicable genomic clustering system, we investigated the interactive landscape of driver mutations in intrahepatic cholangiocarcinoma (ICC). Methods: The genomic data of 1481 ICCs from diverse populations was analyzed to investigate the pair-wise co-occurrences or mutual exclusivities among recurrent driver mutations. Clinicopathological features and outcomes were compared...

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Identifiers

PMID: 34987644
DOI: 10.7150/thno.63417
PMCID: PMC8690927

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