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Article

Mutational landscape of intrahepatic cholangiocarcinoma.

Nature communications - 15 Dec 2014

Zou Shanshan, Li Jiarui, Zhou Huabang, Frech Christian, Jiang Xiaolan, Chu Jeffrey S C, Zhao Xinyin, Li Yuqiong, Li Qiaomei, Wang Hui, Hu Jingyi, Kong Guanyi, Wu Mengchao, Ding Chuanfan, Chen Nansheng, Hu Heping

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is a fatal primary liver cancer (PLC) that affects 5-10% of all PLCs. Here we sequence tumour and matching control sample pairs of a large cohort of 103 ICC patients in China, resulting in the identification of an ICC-specific somatic mutational signature that is associated with liver inflammation, fibrosis and cirrhosis. We further uncover 25 significantly mutated genes...

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Share to Bile Duct Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins p21(ras)

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Source

Identifiers

PMID: 25526346
DOI: 10.1038/ncomms6696

Genes

KRAS
ECE2
EPPK1
FYN
IDH1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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