Article
HIV-1 subtype F integrase polymorphisms external to the catalytic core domain contribute to severe loss of replication capacity in context of the integrase inhibitor resistance mutation Q148H.
The Journal of antimicrobial chemotherapy - 30 Sept 2022
Aulicino Paula C, Momin Zoha, Rozenszajn Mijael, Monzon Arturo, Arazi-Caillaud Solange, Bologna Rosa, Mangano Andrea, Kimata Jason T
Abstract excerpt
BACKGROUND: In prior studies, HIV-1 BF recombinants with subtype F integrases failed to develop resistance to raltegravir through the Q148H mutational pathway. We aimed to determine the role of subtype-specific polymorphisms in integrase on drug susceptibility, viral replication and integration. METHODS: Integrase sequences were retrieved from the Los Alamos Database or obtained from the Garrahan HIV cohort....
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