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Article

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.

mBio - 13 Nov 2024

Dinh Tung, Tber Zahira, Rey Juan S, Mengshetti Seema, Annamalai Arun S, Haney Reed, Briganti Lorenzo, Amblard Franck, Fuchs James R, Cherepanov Peter, Kim Kyungjin, Schinazi Raymond F, Perilla Juan R, Kim Baek, Kvaratskhelia Mamuka

Abstract excerpt

Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are investigational antiretroviral agents that potently impair virion maturation by inducing hyper-multimerization of IN and inhibiting its interaction with viral genomic RNA. The pyrrolopyridine-based ALLINI pirmitegravir (PIR) has recently advanced into phase 2a clinical trials. Previous cell culture-based viral breakthrough assays identified the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39404354
DOI: 10.1128/mbio.00465-24
PMCID: PMC11559089

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PIR

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