Article
E138K and M184I mutations in HIV-1 reverse transcriptase coemerge as a result of APOBEC3 editing in the absence of drug exposure.
AIDS (London, England) - 24 Aug 2012
Fourati Slim, Malet Isabelle, Lambert Sidonie, Soulie Cathia, Wirden Marc, Flandre Philippe, Fofana Djeneba B, Sayon Sophie, Simon Anne, Katlama Christine, Calvez Vincent, Marcelin Anne-Geneviève
Abstract excerpt
BACKGROUND: Recent clinical trials with rilpivirine combined with emtricitabine and tenofovir revealed that patients failing treatment, frequently, harbored viruses encoding resistance-associated mutations in the HIV-1 reverse transcriptase at position E138K and M184I. We show here that APOBEC3 proteins play a role in the emergence of these drug resistance mutations. METHODS: We used a Vif mutant that has...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.