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The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir

2024-01-26

Abstract excerpt

<h4>ABSTRACT</h4> Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are investigational antiretroviral agents which potently impair virion maturation by inducing hyper-multimerization of IN and inhibiting its interaction with viral genomic RNA. The pyrrolopyridine-based ALLINI pirmitegravir (PIR) has recently advanced into Phase 2a clinical trials. Previous cell culture based viral breakthrough assays identifi...

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Literature Corpus work
f8fbf754-7317-5482-95fe-d94fe543e6a9
DOI
10.1101/2024.01.26.577387
Open publication

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The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravirDOI 10.1101/2024.01.26.577387
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