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Article

Multifunctionality of the Telomere-Capping Shelterin Complex Explained by Variations in Its Protein Composition

11 Jul 2021

Abstract excerpt

Protecting telomere from the DNA damage response is essential to avoid the entry into cellular senescence and organismal aging. The progressive telomere DNA shortening in dividing somatic cells, programmed during development, leads to critically short telomeres that trigger replicative senescence and thereby contribute to aging. In several organisms, including mammals, telomeres are protected by a protein complex...

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PMID: 34359923
DOI: 10.3390/cells10071753

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