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Article

Competitive SNP-LAMP probes for rapid and robust single-nucleotide polymorphism detection.

Cell reports methods - 18 Jul 2022

Hyman Leland B, Christopher Clare R, Romero Philip A

Abstract excerpt

In this work, we developed a simple and robust assay to rapidly detect SNPs in nucleic acid samples. Our approach combines loop-mediated isothermal amplification (LAMP)-based target amplification with fluorescent probes to detect SNPs with high specificity. A competitive "sink" strand preferentially binds to non-SNP amplicons and shifts the free energy landscape to favor specific activation by SNP products. We...

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Identifiers

PMID: 35880021
DOI: 10.1016/j.crmeth.2022.100242
PMCID: PMC9308130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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