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Article

ICR-LAMP: A one-pot isothermal assay enabled by transient spatial separation and dynamic ICR for high-specificity SNP genotyping.

Biosensors & bioelectronics - 1 Nov 2026

Dong Juan, Shi Jinyi, Zhao Jun, Chen Xin, Zhan Guoqiang, Du Feng, Cui Xin, Wang Wei, Ding Sheng, Tang Zhuo

Abstract excerpt

Single nucleotide polymorphisms (SNPs) serve as critical genetic markers associated with disease susceptibility, drug response, and pathogen evolution. However, most existing methods fail to simultaneously satisfy high specificity, sensitivity, and operational simplicity, limiting their practical application in decentralized settings. To address this gap, we developed a novel isothermal SNP genotyping approach...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42269452
DOI: 10.1016/j.bios.2026.118914

Genes

ABCB1
ALDH2
CYP2C19
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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