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Article

Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia.

Acta neuropathologica communications - 7 Jul 2022

Miedema Suzanne S M, Mol Merel O, Koopmans Frank T W, Hondius David C, van Nierop Pim, Menden Kevin, de Veij Mestdagh Christina F, van Rooij Jeroen, Ganz Andrea B, Paliukhovich Iryna, Melhem Shamiram, Li Ka Wan, Holstege Henne, Rizzu Patrizia, van Kesteren Ronald E, van Swieten John C, Heutink Peter, Smit August B

Abstract excerpt

Frontotemporal dementia is characterized by progressive atrophy of frontal and/or temporal cortices at an early age of onset. The disorder shows considerable clinical, pathological, and genetic heterogeneity. Here we investigated the proteomic signatures of frontal and temporal cortex from brains with frontotemporal dementia due to GRN and MAPT mutations to identify the key cell types and molecular pathways in...

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Identifiers

PMID: 35799292
DOI: 10.1186/s40478-022-01387-8
PMCID: PMC9261008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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