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Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration

14 Mar 2025

Abstract excerpt

Endothelial cells (ECs) help maintain the blood-brain barrier but deteriorate in many neurodegenerative disorders. Here we show, using a specialized method to isolate EC and microglial nuclei from postmortem human cortex (92 donors, 50 male and 42 female, aged 20-98 years), that intranuclear cellular indexing of transcriptomes and epitopes enables simultaneous profiling of nuclear proteins and RNA transcripts at...

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Alzheimer's disease research and treatments
Amyotrophic Lateral Sclerosis Research
Neuroinflammation and Neurodegeneration Mechanisms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40087396
DOI: 10.1038/s41593-025-01914-5

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