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Article

Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease.

Biochemical Society transactions - 1 Jun 2009

Lindahl Tomas, Barnes Deborah E, Yang Yun-Gui, Robins Peter

Abstract excerpt

The major DNA-specific 3'-5' exonuclease of mammalian cells is TREX1 (3' repair exonuclease 1; previously called DNase III). The human enzyme is encoded by a single exon and, like many 3' exonucleases, exists as a homodimer. TREX1 degrades ssDNA (single-stranded DNA) more efficiently than dsDNA (double-stranded DNA), and its catalytic properties are similar to those of Escherichia coli exonuclease X. However,...

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Identifiers

PMID: 19442247
DOI: 10.1042/BST0370535

Genes

TREX1
ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease.PMID 19442247Read ↗

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