Article
The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
The Journal of biological chemistry - 6 Apr 2007
de Silva Udesh, Choudhury Sumana, Bailey Suzanna L, Harvey Scott, Perrino Fred W, Hollis Thomas
Abstract excerpt
The TREX1 enzyme processes DNA ends as the major 3' --> 5' exonuclease activity in human cells. Mutations in the TREX1 gene are an underlying cause of the neurological brain disease Aicardi-Goutières syndrome implicating TREX1 dysfunction in an aberrant immune response. TREX1 action during apoptosis likely prevents autoimmune reaction to DNA that would otherwise persist. To understand the impact of TREX1...
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