Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Local genetic covariance between serum urate and kidney function estimated with Bayesian multitrait models.

G3 (Bethesda, Md.) - 25 Aug 2022

Lupi Alexa S, Sumpter Nicholas A, Leask Megan P, O'Sullivan Justin, Fadason Tayaza, de Los Campos Gustavo, Merriman Tony R, Reynolds Richard J, Vazquez Ana I

Abstract excerpt

Hyperuricemia (serum urate >6.8 mg/dl) is associated with several cardiometabolic and renal diseases, such as gout and chronic kidney disease. Previous studies have examined the shared genetic basis of chronic kidney disease and hyperuricemia in humans either using single-variant tests or estimating whole-genome genetic correlations between the traits. Individual variants typically explain a small fraction of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Hyperuricemia

Share to Kidney

Share to Renal Insufficiency, Chronic

Share to Uric Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 35876900
DOI: 10.1093/g3journal/jkac158
PMCID: PMC9434310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Local genetic covariance between serum urate and kidney function estimated with Bayesian multitrait models.PMID 35876900Read ↗

Local genetic covariance between serum urate and kidney function obtained from local Bayesian regressionsSemantic proximity Read ↗

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levelsSemantic proximity Read ↗

Large-scale cross-ancestry genome-wide meta-analysis of serum urate.Semantic proximity Read ↗

Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease.Semantic proximity Read ↗

The Shared Genetic Basis of Hyperuricemia, Gout, and Kidney Function.Semantic proximity Read ↗

Metabolic-renal disease genetic architecture revealed by genomic structural equation modeling.Semantic proximity Read ↗

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.Semantic proximity Read ↗

Genetics of serum urate concentrations and gout in a high-risk population, patients with chronic kidney disease.Semantic proximity Read ↗

Shared Genetic Architecture Between Kidney Function and Alzheimer Disease Across AncestriesSemantic proximity Read ↗

Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk FactorsSemantic proximity Read ↗

Shared Genetics of Kidney Function Traits and Bladder Cancer: A Genome-Wide Cross-Trait Analysis.Semantic proximity Read ↗

Discovering Novel Loci of Chronic Kidney Disease via Principal Component Analysis-Based Multiple-Trait Genome-Wide Association Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.