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Article

Discovering Novel Loci of Chronic Kidney Disease via Principal Component Analysis-Based Multiple-Trait Genome-Wide Association Study.

American journal of nephrology - 1 Jan 2025

Chuang Gwo-Tsann, Hsiung Chia-Ni, Che Tony Pan-Hou, Chang Yi-Cheng

Abstract excerpt

INTRODUCTION: Chronic kidney diseases (CKD) encompass a spectrum of complex pathophysiological processes. While numerous genome-wide association studies (GWASs) have focused on individual traits such as albuminuria, estimated glomerular filtration rate (eGFR), and eGFR change, there remains a paucity of genetic studies integrating these traits collectively for comprehensive evaluation. METHODS: In this study, we...

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Albuminuria
Genome-Wide Association Study
Glomerular Filtration Rate
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Principal Component Analysis

Renal Insufficiency, Chronic

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PMID: 39433025
DOI: 10.1159/000541982
PMCID: PMC11975323

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PC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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