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Article

The Shared Genetic Basis of Hyperuricemia, Gout, and Kidney Function.

Seminars in nephrology - 1 Nov 2020

Leask Megan P, Sumpter Nicholas A, Lupi Alexa S, Vazquez Ana I, Reynolds Richard J, Mount David B, Merriman Tony R

Abstract excerpt

Increased urate levels and gout correlate with chronic kidney disease with consensus that the primary driver of this relationship is reduced kidney function. However, a comparison of results of genome-wide association studies in serum urate levels and kidney function indicate a more complex situation. Approximately 20% of loci are shared-comprised of those in which the urate-raising allele associates with reduced...

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Identifiers

PMID: 33678313
DOI: 10.1016/j.semnephrol.2020.12.002

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