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Metabolic-renal disease genetic architecture revealed by genomic structural equation modeling.

Journal of molecular endocrinology - 1 Apr 2026

Ding Kaixi, Xiang Li, Jiang Wei, Lei Ming, Gao Yongxiang

Abstract excerpt

Physiologic mechanisms underlying metabolic and renal diseases interact and are highly comorbid, yet their genetic associations and underlying mechanisms have not been systematically elucidated. Using genome-wide association study (GWAS) summary statistics from UK Biobank, FinnGen, and CKDGen, we integrated and analyzed gout, serum urate, chronic kidney disease, kidney stones, and metabolic syndrome. Using...

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PMID: 41926080
DOI: 10.1530/JME-25-0171

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GCKR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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