Article
A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation.
Biology open - 15 Aug 2022
Chen Tingxu, Alcorn Heather, Devbhandari Sujan, Remus Dirk, Lacy Elizabeth, Huangfu Danwei, Anderson Kathryn V
Abstract excerpt
Formation of a properly sized and patterned embryo during gastrulation requires a well-coordinated interplay between cell proliferation, lineage specification and tissue morphogenesis. Following transient physical or pharmacological manipulations of embryo size, pre-gastrulation mouse embryos show remarkable plasticity to recover and resume normal development. However, it remains unclear how mechanisms driving...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.