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Article

Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage.

Science (New York, N.Y.) - 17 Jan 2014

Zhang Qiao, Shalaby Nevine A, Buszczak Michael

Abstract excerpt

Ribosome biogenesis drives cell growth and proliferation, but mechanisms that modulate this process within specific lineages remain poorly understood. Here, we identify a Drosophila RNA polymerase I (Pol I) regulatory complex composed of Under-developed (Udd), TAF1B, and a TAF1C-like factor. Disruption of udd or TAF1B results in reduced ovarian germline stem cell (GSC) proliferation. Female GSCs display high...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24436420
DOI: 10.1126/science.1246384
PMCID: PMC4084784

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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