Article
Melanoma with in-frame deletion of MAP2K1: a distinct molecular subtype of cutaneous melanoma mutually exclusive from BRAF, NRAS, and NF1 mutations.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2020
Williams Erik A, Montesion Meagan, Shah Nikunj, Sharaf Radwa, Pavlick Dean C, Sokol Ethan S, Alexander Brian, Venstrom Jeff, Elvin Julia A, Ross Jeffrey S, Williams Kevin Jon, Tse Julie Y, Mochel Mark C
Abstract excerpt
While the genomics of BRAF, NRAS, and other key genes influencing MAP kinase (MAPK) activity have been thoroughly characterized in melanoma, mutations in MAP2K1 (MEK1) have received significantly less attention and have consisted almost entirely of missense mutations considered secondary oncogenic drivers of melanoma. Here, we investigated melanomas with in-frame deletions of MAP2K1, alterations characterized as...
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